The sources — every claim's origin

NAD+ References and Sources

Every quantitative claim on this site traces to one of the studies below.

About these sources

Every quantitative claim in this NAD+ digest — each dose, percentage, duration and pharmacokinetic figure — maps to a numbered source below. The list draws on randomized human trials, mechanistic studies and recent reviews, weighted toward peer-reviewed primary literature and current syntheses such as the 2023 and 2025 reviews of NAD+ precursor supplementation. Where a study used a brand name in its own title (for example a trial of a named NR ingredient), the citation reproduces that title verbatim as a matter of accurate referencing; it is not an endorsement of any product. You can read more about this research digest, and the frequently asked questions about NAD+ answer common queries directly.

  1. Yoshino M, Yoshino J, Kayser BD, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372(6547):1224-1229.
  2. Camacho-Pereira J, Tarragó MG, Chini CCS, et al. CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism. Cell Metab. 2016;23(6):1127-1139.
  3. Yi L, Maier AB, Tao R, et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. GeroScience. 2023;45(1):29-43.
  4. Conze D, Brenner C, Kruger CL. Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults. Sci Rep. 2019;9(1):9772.
  5. Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021;22(2):119-141.
  6. Berven H, Kverneng S, Sheard E, et al. NR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinson's disease. Nat Commun. 2023;14(1):7793.
  7. Freeberg KA, Udani R, Bostwick AD, et al. Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions. J Gerontol A Biol Sci Med Sci. 2023;78(12):2435-2448.
  8. Chen AC, Martin AJ, Choy B, et al. A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention. N Engl J Med. 2015;373(17):1618-1626.
  9. Kim LJ, Chalmers TJ, Smith GC, et al. Host-microbiome interactions in nicotinamide mononucleotide (NMN) deamidation. FEBS Lett. 2023;597(17):2196-2220.
  10. Kar A, Mehrotra S, Chatterjee S. CD38: T Cell Immuno-Metabolic Modulator. Cells. 2020;9(7):1716.
  11. Groth B, Venkatakrishnan P, Lin SJ. NAD+ Metabolism, Metabolic Stress, and Infection. Front Mol Biosci. 2021;8:686412.
  12. Aleo MF, Giudici ML, Sestini S, Danesi P, Pompucci G, Preti A. Metabolic fate of extracellular NAD in human skin fibroblasts. J Cell Biochem. 2001;80(3):360-366.
  13. Vinten KT, Trętowicz MM, Coskun E, et al. NAD+ precursor supplementation in human ageing: clinical evidence and challenges. Nat Metab. 2025.
  14. Christen S, et al. The differential impact of three different NAD+ boosters on circulatory NAD and microbial metabolism in humans. Nat Metab. 2026.